Formulation of Peperomia pellucida (L) Kunth extract tablet by modified filler

Nanang Yunarto

Formulation of Peperomia pellucida (L) Kunth extract tablet by modified filler

Abstract


Abstrak
Latar belakang: Peperomia pelusida telah banyak digunakan dalam pengobatan tradisional. Pada saat ini, bentuk-bentuk yang ada masih konvensional seperti jus dan infusum, karena itu, perlu dirumuskan
lebih praktis dan berat seragam seperti bentuk tablet. Tujuan dari penelitian ini adalah untuk mendapatkan formula optimum pelusida tablet ekstrak P. pellucida. Metode: P. pelusida ekstrak tablet yang diproduksi dengan variasi selulosa mikrokristalin (MCC) PH 101
- laktosa dengan metode granulasi basah dalam tiga formula, formula I (100% MCC PH 101), II (laktosa 100%), dan III (MCC PH 101: laktosa = 50%: 50%). Butiran dievaluasi karakteristik fisik termasuk laju
aliran, penyerapan air, dan kompaktibilitas untuk mendapatkan formula optimum dengan menggunakan desain simplex lattice dan jumlah respon. Formula yang digunakan untuk membuat tablet dan diuji
karakteristik fisik (keseragaman bobot, kekerasan, dan kerapuhan dan waktu hancur). Hasil: Laktosa secara signifikan dipengaruhi oleh laju alirannya, sedangkan MCC PH 101 - laktosa dengan metode granulasi basah dalam tiga formula, formula I (100% MCC PH 10PH 101 dipengaruhi penyerapan kompaktibilitas dan air. Berdasarkan karakteristik fisik granul dan jumlah responsnya, kombinasi formula MCC PH 101 80% dan laktosa 20% dapat disimpulkan menjadi yang paling optimal untuk tablet filler. Formula tablet ini yang memiliki karakteristik fisik terbaik dengan berat 620,84 ± 1,04 mg, kekerasan 8,54 ± 0,68 kg, kerapuhan 0,26% ± 0,04 dan waktu hancur 4,58 ± 0,17 menit.
Kesimpulan: Proporsi MCC PH 101 80% dan laktosa 20% merupakan formula optimum terbaik dan memenuhi persyaratan karakteristik fisik tablet. (Health Science Indones 2013;1:32-6) Key words: formulasi, extract P. pellucida, optimal


Abstract
Background: Peperomia pellucida has been widely used in traditional medicine. Recently, its existing forms are still conventional such as juice and infusum; therefore, it needs to be formulated more practically
and in uniform weight such as tablet form. The objective of this research was to get the optimum formula of P. pellucidaextract tablet.
Methods: P. pellucida extract tablets were produced with variation of microcrystalline cellulose (MCC) PH 101 – lactose by wet granulation method in three formulas, formula I (100% MCC PH 101), II (lactose
100%), and III (MCC PH 101: lactose = 50%: 50%). Granules were evaluated their physical characteristics including their flow rate, water absorption and compactibility to obtain the optimum formula by using
simplex lattice design and total response. The optimum formula was used to make tablet and tested its physical characteristics (uniformity weight, hardness, and friability and disintegration time). Results:Lactose significantly  influenced by its flow rate, whereas MCC PH 101 influenced  the compactibility and water absorption. Based on the granules physical characteristics and their total responses, the formula combination of MCC PH 101 80% and lactose 20% was concluded to be the most optimum one for tablet filler. This optimum formula tablet had the best physical characteristics with weigth uniformity of 620.84 ± 1.04 mg, hardness of 8.54 ± 0.68 kg, friability of 0.26% ± 0.04 and disintegration time of 4.58 ± 0.17 minutes. Conclusion: The proportion MCC PH 101 80% and lactose of 20% obtained the best optimum formula and passed requirements of the tablet physical characteristics. (Health Science Indones 2013;1:32-6)
Key words: formulation, P. pellucida extract, optimize


Keywords


formulation, P. pellucida extract, optimize

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Health Science Journal of Indonesia

p-ISSN: 2087-7021
e-EISSN: 2338-3437

Published by : Badan Litbang Kesehatan, Kementerian Kesehatan RI

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