Clinical trial of osteoarthritis jamu formula compare to piroxicam

Danang Ardiyanto, Agus Triyono, Peristiwan Ridha Widhi Astana, Tofan Aries Mana


Latar belakang: Indonesia memiliki beberapa ramuan tradisional yang telah digunakan untuk mengurangi nyeri pada osteoarthritis (OA). Namun belum ada bukti yang kuat mengenai khasiat dan keamanan dari ramuan tradisional. Penelitian ini memberikan bukti mengenai khasiat dan keamanan dari satu ramuan tradisional.

Metode: Penelitian ini menggunakan metode randomized clinical trial (RCT) dengan 123 subyek (pasien) selama 28 hari intervensi. Penelitian ini dilakukan pada bulan Maret – Desember 2014 oleh 30 dokter Saintifikasi Jamu di 20 provinsi. Formula jamu dibandingkan dengan piroksikam sebagai kontrol positif. Parameter yang digunakan untuk mengevaluasi khasiat formula jamu dan piroxicam adalah visual analogue score (VAS), pilot geriatric arthritis project (PGAP) functional status assessment (FSA), dan Short Form (SF)-36. Untuk mengevaluasi keamanan digunakan nilai serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase level (SGPT), blood urea nitrogen (BUN), dan kreatinin.

Hasil: Sebanyak 123 pasien yang dibagi menjadi dua kelompok yaitu 63 subyek pada kelompok formula jamu dan 60 subyek pada kelompok piroksikam. Pemberian jamu dapat menurunkan VAS secara bermakna (p<0,05) jika dibandingkan dengan hari ke-0. Nilai FSA kelompok jamu turun secara bermakna (p=0,000) jika dibandingkan dengan nilai di awal intervensi. Formula jamu dapat memperbaiki nilai SF-36 bila dibandingkan dengan hari ke-0. Nilai ketiga parameter antara jamu formula dan piroksikam, jika dibandingkan tidak berbeda bermakna (p>0,05). Kelompok formula jamu menunjukkan nilai SGOT, SGPT, BUN, dan kreatinin dalam ambang normal.

Kesimpulan: Penelitian ini menunjukkan bahwa ramuan jamu secara klinis, khasiatnya sebanding dengan piroxicam dan aman setelah intervensi selama 28 hari.

Kata kunci: khasiat, keamanan, RCT, ramuan



Background: Indonesian herbs have several formulas which have been used traditionally to reduce pain of osteoarthritis (OA). However, there is a lack of evidence of its efficacy and safety. The objectives of study were to investigate the efficacy and safety of  a traditional formula for OA.

Methods: Design of the study was a randomized clinical trial (RCT) involved 123 patients (subjects) for 28 days intervention. This study was conducted between March - December 2014 with 30 physicians were participated at 20 regencies in Indonesia. The variables measured were VAS score, PGAP functional status assessment (FSA), and Short Form (SF-36) to assess jamu efficacy in comparison to piroxicam. To evaluate the safety of jamu formula using values of SGOT, SGPT, BUN, and creatinine.

Result: The jamu formula administration effects can reduce VAS significantly  (p<0.05)  if it was compared to baseline. FSA score of jamu formula group was decreased significantly (p=0.000) when compared to the start of intervention. Short Form (SF)-36 of jamu formula group were significantly improved when compared with baseline value. The result of the three parameters between jamu group and piroxicam group should not significantly different. There was no difference in those parameters between both groups (p>0.05). In biological parameters, SGPT, SGOT, BUN, and creatinine level, showed normal range in both groups.

Conclusion: This study showed that the efficacy and safety of jamu formula was clinically comparable to piroxicam after 28 days of treatment.

Keywords: efficacy, safety, RCT, jamu formula




American Academy of Orthopaedic Surgeons, “Treatment Of Osteoarthritis Of The Knee Evidence-Based Guideline 2nd Edition Adopted by the American Academy of Orthopaedic Surgeons Board of Directors,” Am. Acad. Orthop. Surg. Board Dir., p. 973, 2013.

De Oliveira Melo M, Aragão FA, Vaz MA. Neuromuscular electrical stimulation for muscle strengthening in elderly with knee osteoarthritis - A systematic review. Complement. Ther. Clin. Pract.2013;19(1):27–31.

Field T, Diego M, Gonzalez G, Funk CG. Knee arthritis pain is reduced and range of motion is increased following moderate pressure massage therapy. Complement. Ther. Clin. Pract.2015;21(4):233–37.

Field T. Knee osteoarthritis pain in the elderly can be reduced by massage therapy, yoga and tai chi: A review. Complement. Ther. Clin. Pract.2016;22:87–92.

Cameron M, Chrubasik S. Oral herbal therapies for treating osteoarthritis (Review). Cochrane Database of Sistematic Reviews.2014;5: CD002947..

Shoara R, Hashempur MH, Ashraf A, Salehi A, Dehshahri S, Habibagahi Z. Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomizedcontrolled clinical trial. Complement. Ther. Clin. Pract.2015;21(3):181–7.

Wang X, Wei S, Liu T, Pang J, Gao N, Ding D, et al. Effectiveness, medication patterns, and adverse events of traditional Chinese herbal patches for osteoarthritis: a systematic review. Evidence-Based Complementary and Alternative Medicine. 2014:1-17.

Ardiyanto D, Ismoyo PT . Studi Klinis Formula Jamu untuk Osteoartritis. Widyariset.2013;16(2):251–8. Indonesian.

Breedveld FC. Osteoarthritis--the impact of a serious disease. Rheumatology (Oxford).2004;43(Suppl 1):i4–i8.

Madeley NJ, Wing KJ, Topliss C, Penner MJ, Glazebrook MA, Younger AS. Responsiveness and validity of the SF-36, Ankle Osteoarthritis Scale, AOFAS Ankle Hindfoot Score, and Foot Function Index in end stage ankle arthritis. Foot & Ankle International. 2012; 33(1), 57-63.

Chou R, Helfand M, Peterson K, Dana T, Roberts C. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis Comparative Effectiveness Review No. 4. (Prepared by the Oregon Evidence-based Practice Center under Contract No. 290-02-0024.) Rockville, MD: Agency for Healthcare Research and Quality. September 2006. Available at:

Basedow M, Runciman WB, March L, Esterman A. Complementary Therapies in Clinical Practice Australians with osteoarthritis ; the use of and beliefs about complementary and alternative medicines. Complement. Ther. Clin. Pract.2014;20(4):237–42.

Elfahmi, Woerdenbag HJ, Kayser O. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J. Herb. Med. 2014;4(2):51–73.

Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A.. Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial, Phytother. Res. 2014. 28(11): 1625–1631. doi: 10.1002/ptr.5174.

Joshi K, Chaturvedi P. Therapeutic efficiency of Centella asiatica (L.) Urb. An underutilized green leafy vegetable: An overview. Int. J. Pharma Bio Sci.2013;4(1):135–149.

Singh D, Mishra M , Gupta M, Singh P, Gupta A, Nema R. Nitric Oxide radical scavenging assay of bioactive compounds present in methanol Extract of Centella asiatica. Int J Pharm Pharm Sci Res. 2012, 2(3): 42-4.

Adnyana IK, Setiawan F, Insanu M. From Ethnopharmacology to clinical study of Orthosiphon stamineus Benth. Int J Pharm Pharm Sci. 2013. 5(3):66-73.

Sharma JN, Al-Omran A, Parvathy SS. Role of nitric oxide in inflammatory diseases. Inflammopharmacology.2007;15(6):252–9.

Ameer OZ, Salman IM, Asmawi MZ, Ibraheen ZO, Yam MF. Orthosiphon stamineus : Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. J. Med. Food.2012;15(8):678–90.

Joseph B, Raj SJ. An overview: pharmacognostic properties of Phyllanthus amarus Linn. Int J Pharmacol. 2011; 7: 40-45.

Amit S, Saraswati B, Kamalesh U, Kumud U. Formulation and evaluation of a novel herbal gel of Equisetum arvense extract. Journal of Pharmacognosy and Phytochemistry. 2013; 1(5):80-86.

Kannappan N, Madhukar A, Mariymmal, et al. Evaluation of nephroprotective activity of Orthosiphon stamineus Benth extract using rat model. Int. J. PharmTech Res.2010;2(1):209–15.

Gupta R, Flora SJS. Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats. J. Appl. Toxicol.2006;26(3):213–22.

Silalahi M, Nisyawati, Walujo EB, et al. The local knowledge of medicinal plants trader and diversity of medicinal plants in the Kabanjahe traditional market, North Sumatra, Indonesia. J. Ethnopharmacol.2015;175:432–43.

Weissner WJ, Munaf A, Ahamed S. Pharmacological Activities of Turmeric (Curcuma longa linn): A Review. Homeopath. Ayurvedic Med.2013;2:1–4.

Full Text: PDF


  • There are currently no refbacks.


Health Science Journal of Indonesia

p-ISSN: 2087-7021
e-EISSN: 2338-3437

Published by : Badan Litbang Kesehatan, Kementerian Kesehatan RI

Visitor of HSJI: View HSJI Stats

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


Health Science Journal of Indonesia has been indexed by :