Karakterisasi Kompleks Inklusi Asam Mefenamat - β -Siklodekstrin yang Dibuat dengan Metode Freeze Drying

Dwi Setyawan, Dewi Isadiartuti

Karakterisasi Kompleks Inklusi Asam Mefenamat - β -Siklodekstrin yang Dibuat dengan Metode Freeze Drying

Abstract


Characterization of mefenamic acid-β-cyclodextrin inclusion complexes by freeze drying method had been studied. Solid state mefenamic acid- β-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamic acid, β-cyclodextrin, mefenamic acid-β-cyclodextrin physical mixture and inclusion complexes were charac­terized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) , Differential Thermal Analyzer (DTA) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and β-cyclodextrin. In vitro dis­solution rate studies of mefenamic acid, mefenamic acid-β-cyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid-β-cyclodextrin inclusion complex showed increasing dissolution rate compared to mefenamic acid-β-cyclodextrin physical mixture and mefenamic acid.

 

Key words: mefenamic acid, β-cyclodextrin, freeze drying, inclusion complex, dissolution rate


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