Studi Klinis Ramuan Jamu Antihipertensi pada Pasien Hipertensi Derajat I

Agus Triyono, Zuraida Zulkarnain, Tofan Aries Mana

Abstract


Hypertension is a risk factor for cardiovascular disease. Hypertension is one of the main causes of high mortality and morbidity in Indonesia. Utilization of medicinal herbs is an  alternative for the treatment of hypertension. The study aimed to determine the efficacy of the herbs combination compared to HCT and evaluated the safety for hypertention stage I. This research method using an open-label randomized clinical trials with intervention for 56 days. Measurement of day-56 (D-56) showed that  herbs decreased sistolic blood pressure to 130.15 + 17.59 mmHg and diastolic at 83.82+9.53 mmHg. There was a significant decrease p = 0.000 (p <0.05) in both systolic and diastolic at the end of intervention. In comparison between combination herbs and HCT, there was not significant difference (p> 0.05), with p mean systolic blood pressure (p = 0.370) and mean diastolic blood pressure (p = 0.412). Liver function parameters (SGOT, SGPT) and renal function (urea, creatinine) is still in normal range at the end of intervention. This study showed that herbs combination was an equally effective compared to HCT and safe for  hypertension stage


Keywords


Jamu; Hypertension; Clinical Study

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