Gambaran Kerusakan Mukosa Usus Mencit (Mus musculus) pada Infeksi Escherichia coli

Dicky Andiarsa, Syarif Hidayat, Dian Eka Setyaningtyas, Sudayat Sudarmawan

Gambaran Kerusakan Mukosa Usus Mencit (Mus musculus) pada Infeksi Escherichia coli


This study was aimed to determine whether the degree of E. coli infection can lead todigestive problems and severity according to the degree of infection. Tests were carriedout in vivo in murine, experimental animals to see the severity of the intestinal mucosa bythe degree of infection.The study was conducted with only post test design with the negative control groupdesign. At the first day of the treatment, group of mice were infected with a suspension of E.coli in volume of 0.1 ml, 0.2 ml, 0.3 ml, 0.4 ml, 0.5 m, 0.6 ml and 0.8 ml, while the control wasgiven sterile distilled water per oral. At days 14 after treatment intestinal surgery andpathological examination were done. Intestinal was opened and cleaned then capturedusing Dinolite Microscope® which connected to the laptop. Data were collected andanalyzed using statistic program and tested using ANOVA to determine differences in thedegree of infection and severity of the intestinal mucosa, in between infected anduninfected of mice.Condition of infected intestinal pathology showed severity depends on the concentrationof a given infection. In the ANOVA analysis showed that there was a significant differencein the volume of a given infection. The more infections level, the poorer condition of theintestinal mucosa of mice. (P = 0,001)

Full Text: PDF


  • There are currently no refbacks.

Jurnal Vektor Penyakit (p-issn: 1978-3647, e-issn: 2354-8835) is published by Balai Penelitian dan Pengembangan Pengendalian Penyakit Bersumber Binatang Donggala.


View My Stats
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International LicenseArticles in the Jurnal Vektor Penyakit are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). These license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.