Review Artikel Mengenal Lebih "Dalam" Schistosomiasis Peran Genome Schistosoma japonicum dalam Interaksi Inang dan Parasit

Anis Nurwidayati

Review Artikel Mengenal Lebih "Dalam" Schistosomiasis Peran Genome Schistosoma japonicum dalam Interaksi Inang dan Parasit

Abstract


In this review is described a draft genomic sequence for the worm. The genome provides a global insight into the moleculer architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation. having a complex nervous system and a well-developed sensory system, S. japonicum can accept stimulation of the corresponding ligands as a physiological response to different environments, such as fresh water or the tissue of its intermediate and mammalian hosts. Numerous proteases, including cercarial elastase, are implicated in mammalian skin penetration and haemoglobinn degradation. The genomic information will serve as s valuable platform to facilitate development of new intervention for schistosomiasis control.

Keywords


genome, schistosoma japonicum, host, parasites

References


Li, Y. S. et al,2007. Large water management Projects schistosomiasis control, Dongting Lake region, China' Emerg- Infect. Dis. 13, 973-979.

Bergquist, R., Utzinget, J. & McManus,2AA8, and D. P. Trick or

treat: the role of vaccines in integrated schistosomiasis control. PLoS Negl. TroP. Dis. 2, e244.

Amiri, P. et al, 1992. Tumour necrosis factor a restores granulomas and induces Parasite egg-laying in schistosome-infected SCID mice-Nature 356,604447.

Davies, S. J. et al, 2001. Modulation of blood fluke development

in the liver by hepatic CD4 Lymphocytes. Science 294, 1358-1361.

Hirai, H. et al, 2000. Chromo somal differentiation of the Schistosoma japonicum complex. Int. J. Parasitol.30, 441-452

Mone', H. &. Boissier, J, 2004. Sexual biology of schistosomes.

Adv. Parasitol. 57, 89-189.

Pice, A. L., Jones, N. C.& Pevzner, P. A, 2005. De novo identification of repeat families in large genomes. Bioinformatics 21, i351-i358. Robb, S. M., Ross, E. & Sanchez Alvarado, A,

SmedGD: the genome database. Nucleic Acids Res. 36, Schmidtea mediterranea Ds99*D606.

Hu, W. et aL,2003. Evolutionary and biomedical implications of a

Schistosoma complementary japonicum DNA resource. Nature Genet. 35,139-147.

Mousley, A., Maule, A. G-. Halton, D. W. & Marks, N. J. 2005. Inter-Phyla studies on neuropeptides: the broad-spectrum potential for anthelmintic and/or endectocide disco very. Parasitology 131, S143-S167.

Holmes, S. P., Barhoumi, R', Nachman,R.J. & Pietrantonio

,P.V,2003. Functional Analysis of a G protein-coupled receptor from

the southern cattle tick Boophilusmicroplus (Acari: Ixodidae) identifies it as the first arttrgpod myokinin receptor: InsecJ Mol.

Biol. 12,27-38.

Cohen, L. M., Neimark, H. & Eveland, L. K, 1980. Schistosoma

mansoni: response of cercariae to a thermal grirdien J. Parasitol. 66,362-364.

Hu, W., Brindley, P. J., McManus, D. P., Feng, Z. & Han,Z. G, 2004. Schistosome transcriptomes: new insights into the parasite

and schistosomiasis. Trends Mol. Med. 10,217-225.

Dvorak, J. et al, 2008. Differential use of protease families for invasion by schistosome cercariae. Biochimie 90, 345-358 .

Dvorak, J. et aL,20A5. Multiple cathepsin B isoform in schistosomula of Trichobi lharzia regenti: idenfication, characterisation and putative role in migration and nutrition. Int. J. Parasitol. 35, 895-9i0 .

Koehler, J. W., Morales, M. E., Shelby, B. D. & Brindley, P.J, 2007. Aspartic protease activities of schistosomes cleave mammalian hemoglobins in a host-specific manner. Mem. Inst. Oswaldo Cruz 102, 83-8s.

Abouel-Nour, M. F., Lotfiz, M., El-Kady, I., El-Shahat, M. & Doughty, B. L, 2005. Localization of leucine aminopeptidase in the

Schistosoma mansoni eggs and in liver tissue from infected mice, J.. Egy,pt-Soc. Parasitol.35, t47-156.

Xu, Y. 2., Shawar, S. M. & Dresden, M. H, 1990. Schistosoma

mansoni: purifi cation and characterization of a membrane-associated leucine aminopeptidase. Exp. Parasitol. 70, 12+-133.

Hillyer, G. V, 2005. Fasciola antigens as vaccines against fascioliasisnd schistosomiasis. J.Helminthol. 7 9, 241-247.

Newport, G.R. et al, 1988. Cloning of the proteinase that facilitates infection by schistosome parasites. J. Biol. Chem. 263,13179-13184.

Wang Shengyue. Han Ze-Guang, Chen Zhu. The Schistosoma

japonicum Genome Sequencing and Functional Analysis Consor-

tium. NATURE Vol (460). www.nature.com/nature


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