DIKLORO DIFENIL TRIKOLOETAN (DDT)

Siti Alfiah

DIKLORO DIFENIL TRIKOLOETAN (DDT)

Abstract


ABSTRACT
Invention of Dikloro Difenil Trikoloetan (DDT) by Zeidler in 1874 was first began of syntetic insectiside discovery. DDT was classified in chlorinated hydrocarbons. Persistance of DDT
in organism and environment have been forbidden to use in  many countries in the world. The resistance of DDT to mosquitoes and flies was reported in 1948. It was caused of change of metabolism, target site insensitivity, phisiology and behaviour mechanism. The problems of DDT could be solved by insecticide substitution which had different method, such as organophosphate and carbamate.

Keywords : DDT, insecticide, organochlorine, resistance

ABSTRAK
Penemuan Dikloro Difenil Trikoloetan (DDT) oleh Zeidler pada tahun 1874 mengawali penemuan insektisida sintetik. DDT tergolong dalam hidrokarbon berklor (chlorinated hydrocarbons
atau organochlorines). DDT tidak mudah terurai dan persisten di organisme maupun lingkungan, akibatnya banyak negara di berbagai belahan dunia melarang penggunaan DDT. Pada tahun 1948 sudah mulai dilaporkan terjadinya resistensi DDT pada nyamuk dan lalat. Resistensi serangga terhadap DDT dikarenakan metabolisme yang berubah, target site insensitivity (resistensi karena gen knock-down resistance), mekanisme fisiologis dan perilaku. Masalah yang timbul akibat DDT dapat
ditangani dengan penggantian insektisida. DDT diganti dengan insektisida yang cara kerjanya berbeda dalam membunuh serangga (resistensi silang negatif), yaitu insektisida golongan
organofosfat atau karbamat.

Kata kunci : DDT, insektisida, organokhlorin, resistensi

Keywords


DDT, insektisida, organokhlorin, resistensi

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Jurnal Kefarmasian Indonesia is a scientific journal published by the Center for Research and Development of Biomedical and Basic Health Technology, Board of Health Research and Development, Ministry of Health of the Republic of Indonesia. The journal publishes original research articles in pharmaceutical science such as Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.

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